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KMID : 0352120150300010031
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Journal of Kyung Hee University
2015 Volume.30 No. 1 p.31 ~ p.37
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The Effect-site Concentration of Propofol Required for the Replacement of an Endotracheal Tube by a ProSeal Laryngeal Mask Airway in Neurosurgical Patients
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Lim Kyung-Jee
Kim Soo-Ryun
Kim Seung-Ju
Kim Seon-Joo
Lee Soo-Kyung
Moon Hyun-Soo
Park Sung-Wook
Kang Hwa-Ja
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Abstract
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Purpose: To determine the target effect-site concentration of propofol required to substitute a ProSeal laryngeal mask airway (PLMA) for an endotracheal tube for providing suitable emergence condition in adult undergoing neurosurgery.
Methods: Anaesthesia was maintained with propofol and remifentanil using target controlled infusion (TCI). After end of surgery, predetermined effect-site concentration of propofol (the starting target concentration of 3.5 μg/ml) and remifentanil 2 ng/ml was held for 10 min. A patient’s response to the endotracheal tube/ PLMA exchange was described as ‘successful’ or ‘unsuccessful’. The propofol concentration of each patient was determined by a modification of Dixon’s up-and.down method steps by 0.5 μg/ml and concentration for exchange in 50% and 95% patients were obtained by a logistic regression model.
Results: The target effect-site concentration of propofol required for successful endotracheal tube/ PLMA exchange in 50% of patients was 3.86±0.21 μ g/ml and the time from an exchange till the removal of LMA was 8.4±5.8 min.
Conclusions: The effect-site concentration of propofol required for endotracheal tube/PLMA exchange in 95% of patients is 4.50 μg/ml.
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KEYWORD
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Endotracheal tube, Laryngeal masks, Propofol, Target-controlled infusion
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